Achievement of the medical team of Andalusia, “personalized” veins

Andres Garcia Leon, head of the angiology and vascular surgery department at Valme Hospital in Seville.

Andres Garcia LeonHead of the Office of Angiology and Vascular Surgery in Valme Hospital in Sevilleis the coordinator of the world ‘s pioneering study and a landmark of Andalusian public health implantation of customized venous segments for the patient from veins from a deceased donor, modified by tissue engineering, and thus be able to treat deep venous insufficiency.

As Garcia points out Medical writingthe project “is a network between different hospitals in Andalusia and with many teams involved”, as the cooperation of multidisciplinary team: from clinical specialists to experts in technology and regulation.

The selection of Hospital Valme to coordinate the project began with a call from the Swedish company Verigraft AB in 2017, which already had the results of animal studies and decided to contact GarcĂ­a Leon and his team as a result of their experience in advanced therapies.

How are personalized veins transplanted? This is the technique used

Use of tissue engineering techniques “We take a healthy vein from the deceased donor patientwhich in principle would not be useful for other types of reconstruction “and the cell of the said donor is eliminated with a bioreactor. Subsequently” we deceleralize the healthy vein “and when we have a recipient, we perform peripheral blood collection, “like when you donate blood”, and with it in the bioractor is re-implanted. “This means that man is always made of cells, we turn someone else’s vein into our own,” Garcia told the newspaper.

In addition, after discharge scheduled two or three days after the intervention, the patient should follow a anticoagulant treatment for one year, during which time the functionality of the transplant is checked and follow-up is performed to check the viability of this vascular segment that has been implanted.

How are suitable patients identified?

Candidate patients are patients who come for consultation in angiology and vascular surgery and through ultrasound femoral vein dysfunction and are diagnosed with deep venous insufficiency. “Subsequently, a number of risk factors must be ruled out in order to have surgery,” the doctor added.

The trial, which is currently in Phase I in Spain after being approved by the Medicines and Health Products Agency in December 2020, has already carried out its first intervention at the Virgen de las Nieves Hospital, a collaborating research center. The full study will include another 14 patients aged between 18 and 75 years with chronic venous insufficiency of the deep venous system.

This therapy, according to Garcia Leon “offers a guarantee of future success”as “so far the only therapeutic path that could be offered to these patients was to wear a healthy compression elastic sock for life or unsuccessful attempts to surgically reconstruct the valves of a diseased vein.”

Although it may contain statements, data or notes from healthcare institutions or specialists, the information contained in Medical Writing is edited and prepared by journalists. We recommend that the reader consult all health issues with a health professional.

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