They find a ″ anti-hunger ″ molecule that is produced after exercise Science and ecology D.V.

A scientific team has identified a molecule in the blood that is produced during sports training and that can effectively reduce food intake and obesity, according to a study published this Wednesday (June 15, 2022) in the journal Nature.

The physiological processes underlying the interaction between exercise and hunger are still poorly understood. To change this, the research team is focusing on understanding how exercises work at the molecular level to capture some of their benefits.

“Regular exercise has been shown to help with weight loss, regulate appetite and improve metabolic profile, especially in overweight and obese people. If we can understand the mechanism by which exercise causes these benefits, then we will be closer to helping . ” many people are improving their health, “said Yong Sue, co-author of the study and a professor at Baylor College of Medicine.

“Older or weak people who can’t move enough may one day benefit from taking a drug that can help reduce osteoporosis, heart disease or other conditions,” added co-author Jonathan Long of Stanford University. .

The effects of the Lac-Phe molecule in mice

To reach their conclusions, the researchers performed a comprehensive analysis of the compounds in the blood plasma of mice after intense running on a treadmill.

The main induced molecule is a modified amino acid called Lac-Phe, synthesized from lactate (a byproduct of intense exercise that is responsible for the burning sensation in muscles) and phenylalanine (an amino acid that is one of the building blocks of proteins).

In mice with diet-induced obesity (fed a high-fat diet), a high dose of Lac-Phe suppressed food intake by approximately 50% for a period of 12 hours without affecting movement or energy expenditure.

When administered to mice for 10 days, Lac-Phe reduced cumulative food intake and body weight (due to weight loss) and improved glucose tolerance.

Tests for horses and people

To continue their research, the researchers also studied the sharp rise in Lac-Phe plasma levels after physical activity in racehorses and humans. Recorded data from human exercise show that sprinting, for example, causes the strongest increase in plasma Lac-Phe, followed by endurance training.

“This suggests that Lac-Phe is an ancient and well-preserved system that regulates nutrition and is associated with physical activity in many animal species,” Long said.

The team’s next steps include looking for more details on how this molecule regulates its effects in the body, including the brain: “Our goal is to learn how to modulate this path of therapeutic intervention exercises,” Sue concluded.

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